Pamelor (Nortriptyline)

Pamelor Review

Nortriptyline is a second generation tricyclic antidepressant marketed as the hydrochloride under the trade names Aventyl®, Pamelor® and Nortrilen®. It is used in the treatment of depression and childhood nocturnal enuresis. In addition it is sometimes used for chronic pain modification, migraine, and labile affect in some neurological conditions.

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Pamelor Drug Class and Mechanism

Nortriptyline is an antidepressant medication of the tricyclic class. Medications in this class are often referred to as tricyclic antidepressants, or TCAs. Depression is an all-pervasive sense of sadness and gloom. In some patients with depression, abnormal levels of brain neurotransmitters (chemicals that the nerve cells use to communicate with each other) may be responsible for the depression. Nortriptyline elevates the mood ("anti-depresses") by raising the level of neurotransmitters in brain tissue.

Pamelor Uses

Active Ingredient: nortriptyline hydrochloride USP. Inactive Ingredients: alcohol, benzoic acid, flavoring, purified water, and sorbitol.For depression: low starting doses are used, increasing as necessary to 75–100mg (0–50mg for adolescents and the elderly). Maximum daily dosage is 150mg.[5] For the management of nocturnal enuresis: lower dosages are used with the maximum period of treatment, including gradual withdrawal, being three months and a full examination including electrocardiogram (ECG or EKG) required before further courses.

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Pamelor Side Effects

Dry mouth, drowsiness, orthostatic hypotension, urinary retention, constipation, and rapid or irregular heartbeat. Some sexual side effects may be a problem as well. Less commonly, seizures and ECG/EKG changes have been reported, especially in overdose. Alcohol may exacerbate some of its side effects and should be avoided. However, the incidence of side effects with nortriptyline is somewhat lower than with the first generation tricyclics

Pamelor Pregnancy

Safe use of Pamelor® (nortriptyline HCl) during pregnancy and lactation has not been established; therefore, when the drug is administered to pregnant patients, nursing mothers, or women of childbearing potential, the potential benefits must be weighed against the possible hazards. Animal reproduction studies have yielded inconclusive results.

Pamelor Overdose

The symptoms and the treatment of an overdose are largely the same as for the other tricyclic antidepressants.

Pamelor More Information

Read the Medication Guide that comes with you or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Talk to your, or your family member's, healthcare provider about: all risks and benefits of treatment with antidepressant medicines all treatment choices for depression or other serious mental illness